"The true division of humanity is between those who live in light and those who live in darkness. Our aim must be to diminish the number of the latter and increase the number of the former. That is why we demand education and knowledge"
-- Victor Hugo

Dr. Richard A. Davis was a part-time faculty member of the Toxicology Program at the University of Medicine and Dentistry of New Jersey, School of Health Related Professions. He taught lecture, laboratory, research and seminar courses in toxicology. He was also responsible for direction of the Toxicology Student Internship Program and participates in the development and conduct of continuing education courses for the professional community. Dr. Davis was also an adjunct faculty member at Georgian Court College and taught a toxicology course as part of the Graduate Program in Biology. The course is a broad overview of adverse effects of chemicals on living organisms, underlying molecular mechanisms causing environmental damage by toxic substances, identification and testing of toxic substances, and safety evaluations related to environmental and industrial toxicology. The goal of the course is to give graduate students in biology a basic understanding of the methods used to assess adverse effects on all levels of biological systems.

Courses and lecture topics taught by Dr. Davis at UMDNJ include Regulatory Toxicology, Organ System Toxicity, Principles of Pharmacology for the Toxicologist, and Research in Toxicology . Each course is described below.

Regulatory Toxicology

Classroom presentations are included on federal, state and local governmental approaches and programs for controlling exposure to toxic chemicals. Identification of legislation and agencies involved in the regulation of chemical categories including food, drugs, cosmetics, pesticides, industrial chemicals, air and water pollutants and hazardous wastes. The use of toxicological data by regulators to assess safety and the impact of regulatory requirements on toxicology studies are discussed. Strategies for internet information access are presented.

Course Objectives

Learning Objectives

UNIT I - Role of Toxicology in Safety Regulation

UNIT II - Hazard Classification and Communication

UNIT III - Safety Assessment

UNIT IV - Risk Assessment

UNIT V - Food Additives

UNIT VI - Drugs / Medical Devices

UNIT VII - Chemicals / Consumer Products

UNIT VIII - Pesticides

UNIT IX - Occupational Safety and Health

UNIT X - Air and Water Pollution

UNIT XI - Hazardous Waste

UNIT XII - Emergency Response / Right-to-Know

Organ System Toxicity

Classroom instruction in organ and physiologic system dysfunction following exposure to toxic agents with emphasis on diagnostic techniques. Selected topics include: genotoxicity; carcinogenicity; teratology, toxicity of the central nervous; reproductive, respiratory and hematological systems; hepatic, renal, dermal and ocular toxicity.

Course Objctives

Learning Objectives

UNIT I - Genetic Toxicity

UNIT II - Carcinogenicity

UNIT III - Reproductive Toxicity

UNIT IV - Renal Toxicity

UNIT V - Developmental Toxicology

UNIT VI - Neurotoxicity

UNIT VII - Hepatotoxicity

UNIT VIII - Respiratory System Toxicity

IX - Dermal / Ocular Toxicity

UNIT X - Hematologic Toxicity

UNIT XI - Immunotoxicity

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Principles of Pharmacology for Toxicologists

Lecture (43 hours) and laboratory (50 hours) course introducing fundamental pharmacologic principles applied to toxicology including receptor concept, dose-response relationship, fate of chemicals in the body, kinetics, factors influencing toxic response, and methods of toxicity testing. At the completion of this course, the student will be able to analyze the relation­ship between toxic chemical exposure and biological effects using basic principles and concepts. A team of faculty members presents lectures for this course. Only topics covered by Dr. Davis are shown below

Course Objectives

Labratory Exercises:

  1. Introduction to Animal Handling, Injection Techniques, Collection of Specimens
  2. Establishing a Dose-Response Curve
  3. Metabolic Enzyme Induction/Inhibition
  4. Plasma Kinetics
  5. Skin Sensitization
  6. Reproduction/Teratology

Lecture Learning Objectives:

UNIT III - Factors Affecting Absorption, Distribution and Excretion

UNIT V - Pharmacokinetics

UNIT VII - Allergic Sensitization

UNIT IX - General Toxicity Testing

UNIT X - Special Toxicity Tests

UNIT XI - Good Laboratory Practice

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Research in Toxicology I

Independent study in toxicology under faculty supervision. Includes instruction in experimental design and methodologies and techniques of literature review and submission of a written proposal. The student will develop and refine organizational, problem solving and critical thinking skills through supervised, independent study of a toxicology research topic of appropriate scope culminating in the preparation of a written research proposal. Content of individual student experiences will vary depending on the interest of the supervising faculty member and project selected.

Course Objectives

Under faculty supervision the student will:

Research in Toxicology II

According to the written proposal developed in RESEARCH IN TOXICOLOGY I, the student will develop and refine organizational, problem solving and critical thinking skills by completing a supervised, independent study of a toxicology research topic. Research will be conducted, data will be analyzed and a written report will be prepared. Content of individual student experiences will vary depending on the interest of the supervising faculty member and project selected.

Course Objectives

Under faculty supervision the student will:

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